Indianapolis, IN - August 27, 2007

Dow AgroSciences LLC, a wholly owned subsidiary of The Dow Chemical Company, announced the signing of a license agreement with the University of Guelph, Canada, that provides Dow AgroSciences with exclusive rights to the leukotoxin antigen LKT-50.  Researchers at the University of Guelph have isolated and modified the gene for the native antigen which produces an immune response against Mannheimia haemolytica, or “shipping fever,” a common respiratory infection in cattle.   The University of Guelph will soon receive a U.S. patent on LKT-50.

Shipping fever pneumonia is the leading cause of death and economic loss for the cattle industry.  The bacterium Mannheimia haemolytica (or Pasteurella haemolytica) infects the lower respiratory tract and causes pneumonia during times of stress, adverse climatic conditions, and respiratory viral infection.

Dow AgroSciences Animal Health has licensed the gene from Guelph to use in its Concert^TM Plant-Cell-Produced System to develop a vaccine.  “We are excited by the potential of this technology to facilitate the development of mucosal immunity which could provide excellent protection against Mannheimia heamolytica infections in cattle,” said Jennifer Rice, DVM, PhD, MBA, Animal Health global product development leader for Dow AgroSciences.

Dow AgroSciences’ Concert system is a new technology that utilizes plant cells instead of whole plants to produce vaccines in a secure, bio-contained environment. This plant-cell-produced process results in subunit vaccines that use only the necessary parts of the bacteria to stimulate immunity to prevent disease without stressing the animal.

“Respiratory disease is a major source of illness in cattle and in this partnership with Dow AgroSciences, we are moving into the next generation of effective vaccines -- going from conventional vaccine technology into plant-cell-produced and potentially, to edible plant-made formats,” notes Patricia Shewen, DVM, PhD, professor, Immunology, Department of Pathobiology,
University of Guelph.

Researchers at the University of Guelph are continuing their research and testing of genetically modified alfalfa to produce the antigens and is testing edible vaccine technology to speed up the vaccination of large herds of cattle to protect against shipping fever.

About Dow AgroSciences LLC
Dow AgroSciences LLC, based in Indianapolis, Indiana, USA, is a top tier agricultural company providing innovative crop protection, pest and vegetation management, seed, and agricultural biotechnology solutions to serve the world's growing population.  Global sales for Dow AgroSciences, a wholly owned subsidiary of The Dow Chemical Company, are $3.4 billion. Learn more at www.dowagro.com

About the University of Guelph
The University of Guelph is renowned in Canada and around the world as a research-intensive and learner-centered institution and for its commitment to open learning, internationalism and collaboration. Our vision is to be Canada's leader in creating, transmitting and applying knowledge to improve the social, cultural and economic quality of life of people in Canada and around the world.

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For Editorial Information:

Robyn Heine
Dow AgroSciences LLC
317.337.4807